| Date | Opponent | Location | Result | Stats |
|---|---|---|---|---|
| 8/31/19 | vs. Florida Atlantic | Columbus, Ohio | W, 45-21 | Box Score (PDF) |
| 9/7/19 | vs. Cincinnati | Columbus, Ohio | W, 42-0 | Box Score (PDF) |
| 9/14/19 | at Indiana | Bloomington, Ind. | W, 51-10 | Box Score (PDF) |
| 9/21/19 | vs. Miami (Ohio) | Columbus, Ohio | W, 76-5 | Box Score (PDF) |
| 9/28/19 | at Nebraska | Lincoln, Neb. | W, 48-7 | Box Score (PDF) |
| 10/5/19 | vs. Michigan State | Columbus, Ohio | W, 34-10 | Box Score (PDF) |
| 10/18/19 | at Northwestern | Evanston, Ill. | W, 52-3 | Box Score (PDF) |
| 10/26/19 | vs. Wisconsin | Columbus, Ohio | W, 38-7 | Box Score (PDF) |
| 11/9/19 | vs. Maryland | Columbus, Ohio | W, 73-14 | Box Score (PDF) |
| 11/16/19 | at Rutgers | Piscataway, N.J. | W, 56-21 | Box Score (PDF) |
| 11/23/19 | vs. Penn State | Columbus, Ohio | W, 28-17 | Box Score (PDF) |
| 11/30/19 | at Michigan | Ann Arbor, Mich. | W, 56-27 | Box Score (PDF) |
| 12/7/19 | vs. Wisconsin (Big Ten Championship Game) | Indianapolis, Ind. | W, 34-21 | Box Score (PDF) |
| 12/28/19 | vs. Clemson (Fiesta Bowl - CFP Semifinal) | Glendale, Ariz. | L, 29-23 | Box Score (PDF) |
